Measuring pharmacodynamics is crucial for drug development, but traditional pharmacodynamic studies based on tissue dissection and subsequent biochemical analysis are labor- and resource-intensive. We developed a non-invasive imaging method to efficiently and rapidly visualize the pharmacodynamics of kinase inhibitors and degraders using an engineered kinase-modulated bioluminescent indicator.
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Change history
26 February 2025
A Correction to this paper has been published: https://doi.org/10.1038/s41589-025-01865-9
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This is a summary of: Wu, Y. et al. Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator. Nat. Chem. Biol. https://doi.org/10.1038/s41589-025-01846-y (2025).
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Visualizing drug effects over time in live animals using optical pharmacodynamics. Nat Chem Biol 21, 1136–1137 (2025). https://doi.org/10.1038/s41589-025-01847-x
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DOI: https://doi.org/10.1038/s41589-025-01847-x
