Extended Data Fig. 8: Additional data related to HDX-MS experiments.
a, Size-exclusion chromatograms obtained during purification of the mGluR2 LBD dimer (left) and the full-length mGluR2 dimer (right). b, Uptake plots presented as mean uptake with data from over three independent replicates overlaid as individual points, for regions of interest shown in Fig. 4. c,d, Woods plot demonstrating deuteration differences for mGluR2 LBD alone, 0 mM Glu versus 10 mM Glu (c) and in the absence or presence of glutamate, for the LBD dimer versus the full-length mGluR (d).
