Extended Data Fig. 1: Strategy for designing, optimizing, and screening KinprolaPKA.
From: Molecular recording of cellular protein kinase activity with chemical labeling
(a) Flowchart of the KinprolaPKA development process. PAABD: phosphoamino acid binding domain; PKAsub: PKA substrate peptide; Hpep: Halo peptide. (b) Amino acid sequence of KinprolaPKA, with the targeting sequence, domains, linkers, phosphorylation site, and mutated site annotated.
