Promyelocytic leukemia (PML) nuclear bodies (NB) facilitate the proteasomal degradation of protein aggregates through the SUMO-targeted ubiquitin ligase pathway. A study now reveals a non-proteolytic role for PML-NBs in preventing TDP-43 aggregation that still relies on the SUMOylation–ubiquitylation cascade but uses it to direct protein aggregates towards p97 ATPase-mediated disaggregation.
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Yu, X., Zhang, H. Come get dissolved in PML bodies. Nat Chem Biol 21, 1306–1307 (2025). https://doi.org/10.1038/s41589-025-01960-x
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DOI: https://doi.org/10.1038/s41589-025-01960-x
