Extended Data Fig. 6: Comparison of local resolution, nucleotide binding in AAA1, AAA3, AAA4, and sensor-I loop conformation in MD-A of the Phi and PhiL-Lis1.
From: Nde1 promotes Lis1 binding to full-length autoinhibited human dynein 1
Local resolution, and nucleotide binding states in MD-A at AAA1, AAA3, and AAA4 of the Phi (a) and PhiL-Lis1 (b). MD-A and -B share the same nucleotide binding in AAA1, AAA3, and AAA4 across both the Phi and PhiL-Lis1. The sensor-I loop adopts almost the same conformation in MD-A (or -B) of both Phi (c) and PhiL-Lis1 (d), indicating that Lis1 binding does not affect phosphate release. The color scheme is the same as Fig. 4.
