Correction to: Nature Chemical Biology https://doi.org/10.1038/s41589-025-01993-2, published online 25 August 2025.

In the version of this article initially published, the current XIST-L1 panel in Extended Data Fig. 3a was a duplicate of the XIST-L3 panel in Extended Data Fig. 3b. The figure has been updated in the HTML and PDF versions of the article.