Fig. 2: Computational scaffolding of single and multiepitope immunogens.
From: Accurate single-domain scaffolding of three nonoverlapping protein epitopes using deep learning
a, Epitopes targeted for single-epitope and multiepitope immunogen design highlighted on RSVF structure (PDB 5TPN) and the antibody variable domain against site V (PDB 5TPN), site IV (PDB 3O45) and site II (PDB 3IXT) are represented by the corresponding colored surfaces. b, Multimotif scaffolding uses motif templates as input for RFjoint2. Template inputs are invariant to global three-dimensional position; hence, by inputting each motif in a separate template, the relative position of the three motifs is not specified a priori; instead, RFjoint2 builds a scaffold (gray protein) that supports the three motifs (colors) in a non-native position with respect to each other.
