Fig. 4: Immunogenicity of single-epitope and multiepitope immunogens.
From: Accurate single-domain scaffolding of three nonoverlapping protein epitopes using deep learning
a, Four groups of mice (n = 5) were immunized with either RSVF or nanoparticle immunogens or a heterologous RSVF primed scheme. b, RSVF reactive endpoint titers on day 56 measured by ELISA. Bars indicate the median. c, Self-reactive titers of mouse groups immunized with nanoparticle immunogens on day 56. d, Site-specific endpoint titers for homologous immunization groups. e, RSV serum-neutralizing titers from pooled group sera on day 56. The plot indicates calculated neutralization titers from triplicate experiments after luminescence normalization, with bars indicating the mean and s.d. f, Site-specific endpoint titers for heterologous boosted immunization groups.
