Fig. 3: Structures of TRPC4/5 in complex with E/Z isomers of efficacy photoswitches.
From: Ideal efficacy photoswitching for chromocontrol of TRPC4/5 channel functions in live tissues
a–d, hTRPC5:E/Z-AzHC complexes (E: 2.6 Å, PDB 9G4Y, EMD-51074; Z: 2.9 Å, PDB 9G50, EMD-51076; C1 symmetry). Note the flip of the distal azobenzene ring. e–h, TRPC4DR:E/Z-AzPico complexes (E: 3.0 Å, PDB 9FXL, EMD-50850; Z: 3.1 Å, PDB 9FXM, EMD-50851; C1 symmetry). Each complex’s best-resolved xanthine-binding site is highlighted. Two-dimensional maps of ligand–protein interactions are shown.
