Fig. 5: Hetero-PINCHs can simultaneously coprecipitate two targets. | Nature Chemical Biology

Fig. 5: Hetero-PINCHs can simultaneously coprecipitate two targets.

From: A pharmacological modality to sequester homomeric proteins

Fig. 5: Hetero-PINCHs can simultaneously coprecipitate two targets.

a, WB and structure of EL230 after 20 h of treatment in Mino cells. b, EL230 tested in a BCL6-positive cell line (OCI-AML2) and in a BCL6-negative cell line (HEK 293) after 20 h of treatment, showing inactivity in the latter. c, Monomeric versions of EL230, based on BCL6 and Keap1 ligands with linkers, tested after 20 h of treatment in Mino cells. All WBs shown here are representative results from n = 2 independent experiments.

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