The interface between biomolecular condensates and cellular membranes underlies many biological processes, yet how biomolecules and lipids reciprocally influence one another’s phase behavior remains poorly understood. A study now shows that membrane composition modulates biomolecular condensation on the membrane, pointing to a new regulatory mechanism of condensation in cells.
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References
Lingwood, D. & Simons, K. Science 327, 46–50 (2010).
Shelby, S. A. & Veatch, S. L. T. Cold Spring Harb. Perspect. Biol. 15, a041395 (2023).
Zhao, Y. G. & Zhang, H. Dev. Cell 55, 30–44 (2020).
Chung, J. K. et al. Biophys. J. 120, 1257–1265 (2021).
Wang, H.-Y. et al. Sci. Adv. 9, eadf6205 (2023).
Bagheri, Y., Rouches, M., Machta, B. & Veatch, S. L. Nat. Chem. Biol. https://doi.org/10.1038/s41589-025-02082-0 (2025).
Lauwers, E., Goodchild, R. & Verstreken, P. Neuron 90, 11–25 (2016).
Chen, X., Wu, X., Wu, H. & Zhang, M. P. Nat. Neurosci. 23, 301–310 (2020).
Pombo-García, K., Adame-Arana, O., Martin-Lemaitre, C., Jülicher, F. & Honigmann, A. Nature 632, 647–655 (2024).
Phillips, M. J. & Voeltz, G. K. Nat. Rev. Mol. Cell Biol. 17, 69–82 (2016).
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Moran, K.K., Snead, W.T. Phases align at the membrane. Nat Chem Biol (2026). https://doi.org/10.1038/s41589-026-02144-x
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DOI: https://doi.org/10.1038/s41589-026-02144-x
