Understanding how lipids and proteins interact in living cells is a long-standing challenge. Coupling localized lipid production with proximity proteomics, Tei et al. identified transporters that act on phosphatidic acid. In doing so, they lay out a workflow that could be harnessed for other aspects of membrane homeostasis.
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References
van Meer, G., Voelker, D. R. & Feigenson, G. W. Nat. Rev. Mol. Cell Biol. 9, 112–124 (2008).
Hamaï, A. & Drin, G. Biochimie 227, 85–110 (2024).
Tei, R., Li, X.-L., Luan, L. & Baskin, J. M. Nat. Chem. Biol. https://doi.org/10.1038/s41589-025-02104-x (2026).
Tei, R., Bagde, S. R., Fromme, J. C. & Baskin, J. M. Nat. Chem. 15, 1030–1039 (2023).
Tei, R. & Baskin, J. M. J. Cell Biol. 219, e201907013 (2020).
Branon, T. C. et al. Nat. Biotechnol. 36, 880–887 (2018).
Seedorf, U., Ellinghaus, P. & Roch Nofer, J. Biochim. Biophys. Acta 1486, 45–54 (2000).
Chen, P.-H. B., Li, X.-L. & Baskin, J. M. Chem. Rev. 125, 2502–2560 (2025).
Moore, W. M. et al. Nat. Chem. Biol. 22, 128–139 (2026).
Li, X.-L., Tei, R., Uematsu, M. & Baskin, J. M. ACS Cent. Sci. 10, 543–554 (2024).
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Seidel, O.J., Budin, I. How to catch a lipid transporter. Nat Chem Biol 22, 674–675 (2026). https://doi.org/10.1038/s41589-026-02153-w
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DOI: https://doi.org/10.1038/s41589-026-02153-w
