Supplementary Figure 2: CXCL10 concentrations are increased by virus infection.
From: Inflammation induced by influenza virus impairs human innate immune control of pneumococcus
(a), Concentrations of CXCL10 at day 0 in the LAIV cohort, measured by Luminex in nasosorption (n = 77). (b), Concentrations of CXCL10 at day 5 to S. pneumoniae inoculation in a cohort with known viral URT state measured by ELISA (n = 82). Oropharyngeal swabs collected 5 d before S. pneumoniae inoculation were assessed for a viral multiplex PCR panel for detection of influenza A and B (n = 0), respiratory syncytial virus (n = 2), human metapneumovirus (n = 0), human rhinovirus (n = 12), parainfluenza viruses 1–4 (n = 1), and coronaviruses OC43, NL63, 229E, and HKU1 (n = 5). Individual volunteers are shown and box plots depict median and interquartile ranges, with whiskers extending to 1.5 × interquartile range or maximum value, per group. *P = 0.017, **P = 6.2 × 10–5 by two-tailed Mann–Whitney test.
