Supplementary Figure 2: Gene Ontology enrichment analysis.
From: SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection
(a, b) Gene Ontology enrichment analysis was performed using topGO R package on differentially expressed genes (DEGs) having |logFC(FPKM)| ≥ 0.5 (n = 1098 genes; 707 up and 391 down) in SFR KO iNKT cells, compared to WT iNKT cells. Corresponding expression profiles of genes annotated with the top 2 most significant GO terms from the Biological Process ontology are shown (GO: 0000278 and 0007049), related to Fig. 1d. Red arrows indicate Bcl2 and Mki67 genes. (c) Expression profiles of genes annotated with T cell receptor signaling pathway from KEGG Pathway are shown (KEGG: 04660). (d) Expression profiles of genes encoding known T cell exhaustion markers are shown. Two independent mice of each genotype were analyzed.
