In contrast with the classical dogma that the pathways generating either memory or ‘exhausted’ T cells are strictly segregated, data now identify a clonally distinct hybrid memory T cell subpopulation with an exhausted phenotype.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Bacterial-adjuvant liquid metal nanocomposites for synergistic photothermal immunotherapy
Advanced Composites and Hybrid Materials Open Access 19 September 2025
-
Distinct CD8 T Cell Populations with Differential Exhaustion Profiles Associate with Secondary Complications in Common Variable Immunodeficiency
Journal of Clinical Immunology Open Access 19 May 2022
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. Annu. Rev. Immunol. 37, 457–495 (2019).
Blank, C. U. et al. Nat. Rev. Immunol. 19, 665–674 (2019).
Galletti, G. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0791-5 (2020).
Kallies, A., Zehn, D. & Utzschneider, D. T. Nat. Rev. Immunol. 20, 128–136 (2020).
Utzschneider, D. T. et al. J. Exp. Med. 213, 1819–1834 (2016).
Rendeiro, A. F. et al. medRxiv https://doi.org/10.1101/2020.09.08.20189092 (2020).
Zhang, J.-Y. et al. Nat. Immunol. 21, 1107–1118 (2020).
Alfei, F. et al. Nature 571, 265–269 (2019).
Sekine, T. et al. Sci. Immunol. 5, eaba7918 (2020).
Wieland, D. et al. Nat. Commun. 8, 15050 (2017).
Utzschneider, D. T. et al. Nat. Immunol. 21, 1256–1266 (2020).
Yao, C. et al. Nat. Immunol. 20, 890–901 (2019).
Khan, O. et al. Nature 571, 211–218 (2019).
Scott, A. C. et al. Nature 571, 270–274 (2019).
Seo, H. et al. Proc. Natl Acad. Sci. USA 116, 12410–12415 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Chu, T., Berner, J. & Zehn, D. Two parallel worlds of memory T cells. Nat Immunol 21, 1484–1485 (2020). https://doi.org/10.1038/s41590-020-00815-y
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41590-020-00815-y
This article is cited by
-
Bacterial-adjuvant liquid metal nanocomposites for synergistic photothermal immunotherapy
Advanced Composites and Hybrid Materials (2025)
-
Distinct CD8 T Cell Populations with Differential Exhaustion Profiles Associate with Secondary Complications in Common Variable Immunodeficiency
Journal of Clinical Immunology (2022)
