Extended Data Fig. 4: Transcriptional differences between ID3⁺ and ID3^- P14 T cells in acute and chronic infection.

Congenically marked Id3^GFP P14 T cells were transferred into naïve mice, which were then infected with either LCMV Armstrong or Docile. ID3⁺ and ID3^- P14 T cells from Armstrong infected mice were FACS purified for RNAseq analysis as described in Fig. 4. a, b, Volcano plots show differentially expressed (DE) genes between ID3⁺ and ID3^- P14 T cells obtained from Armstrong infected mice on day 5 p.i. (a) and day 21 p.i. (b). c, Number of DE genes in all comparisons including comparisons shown in Fig. 4a, b. Number of genes upregulated in ID3⁺ compared to ID3^- P14 T cells are indicated in red and genes downregulated in ID3⁺ P14 T cells are indicated in blue.