Extended Data Fig. 6: The Pdcd1 gene locus displays early enhanced accessibility in T cells responding to LCMV Docile infection.
From: Early precursor T cells establish and propagate T cell exhaustion in chronic infection
Congenically marked Id3GFP P14 T cells were transferred into naïve mice, which were then infected with either LCMV Armstrong or Docile. ID3+ and ID3- P14 T cells were FACS purified at days 5 and 21 p.i. and ATAC sequencing was performed. Chromatin accessibility of the Pdcd1 locus is shown. Red arrows highlight regions that are differentially accessible between T cells obtained from Armstrong (green tracks) compared to Docile infected mice (black tracks). ATAC seq analysis was performed with two experimental replicates at each time point. Open chromatin tracks are based on merged replicates.
