Extended Data Fig. 8: Late precursor T cells retain higher levels of TOX and PD-1 after expansion in acute infection. | Nature Immunology

Extended Data Fig. 8: Late precursor T cells retain higher levels of TOX and PD-1 after expansion in acute infection.

From: Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Extended Data Fig. 8: Late precursor T cells retain higher levels of TOX and PD-1 after expansion in acute infection.The alternative text for this image may have been generated using AI.

a, Experimental scheme. Congenically marked Id3GFP P14 T cells were transferred into naïve mice, which were infected with LCMV Docile. 5 or 26 days p.i., ID3+TIM-3- TP and ID3-TIM-3+ TE P14 T cells were FACS sorted and transferred into naïve mice, which were infected with Armstrong. Donor P14 T cells were analysed 7 days post infection. b, Fold expansion of donor T cell populations. c, d, MFI of TOX (c) and PD-1 (d) of donor P14 T cells. Symbols represent individual mice. Data are representative or combined of two experiments with at least 3 mice per group. Statistical analysis was unpaired Student’s t test (two-tailed). ****p < 0.0001; ***p < 0.001; **p < 0.01; ns, not significant.

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