Extended Data Fig. 2: Memory T cells in acutely-resolved infection express low levels of TOX and high amounts of IFN-γ.
From: Early precursor T cells establish and propagate T cell exhaustion in chronic infection
P14 T cells were transferred into congenically marked naïve recipient mice, which were infected with either LCMV Armstrong or Docile and analysed on day 21 p.i. a, TOX expression of TCF1+ precursor (TP, black solid dots) and TIM-3+ effector (TE, black open dots) P14 T cells from Docile compared to memory P14 T cells from Armstrong (green solid dots) infection. b, Frequencies of IFN-γ producing TP and TE P14 T cells from Docile compared to memory P14 T cells from Armstrong after ex vivo re-stimulation with LCMV-derived gp33 peptide. TP and TE cell segregation based on Ly108 and TIM-3 expression. Symbols represent individual mice; lines connect P14 T cells within the same host. Data are representative of at least three independent experiments with at least four mice per group. Statistical analysis was performed with unpaired Student’s t test (two-tailed). ****p < 0.0001; ***p < 0.001.
