Extended Data Fig. 7: Evaluation of the sera from donor mice, related to Figs. 3f,g.
a,b, The pooled serum from donors were tested for ZIKV-E-specific IgG (a) and NAb titers (b). The dashed line indicates the LOD. c, ADE activities of the pooled donor sera in cell culture. Shown are the enhancement curves of K562 cells infected with DENV1, DENV2, DENV3, and DENV4, respectively, in the presence of serially diluted immunized mice sera as indicated. Infected cells were quantified by flow cytometry. Relative infectivity for each sample were normalized to the peak infectivity of mAb Z6.
