Extended Data Fig. 2: Comparison of FLE mAbs bound to flavivirus-E. | Nature Immunology

Extended Data Fig. 2: Comparison of FLE mAbs bound to flavivirus-E.

From: Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch

Extended Data Fig. 2: Comparison of FLE mAbs bound to flavivirus-E.

a, Z6 bound to ZIKV-sE. Z6 Fab is colored in green and ZIKV-sE is colored in grey. FL is highlighted in magenta. b, 2A10G6 bound to ZIKV-sE (PDB: 5JHL). 2A10G6-Fab is colored in cyan and ZIKV-sE is colored in grey. FL is highlighted in magenta. c, E53 bound to WNV-sE (PDB: 3I50). E53 Fab is colored in orange and ZIKV-sE is colored in grey. FL is highlighted in magenta. d, The Z6, 2A10G6 and E53 bound to E are overlapped, showing different approaching angles. e, The E residues participating in interactions of antibodies are listed. The numbers of contacts are highlighted for the main contributors in each sE.

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