Extended Data Fig. 3: Quantitation of innate and adaptive cell subsets.

Cd23^Cre/+ and Bmi1^f/fCd23^Cre/+ mice were infected with LCMV-Docile. a, Mouse weights assessed at the indicated time points post-infection (n = 18 Cd23^Cre/+ and n = 19 Bmi1^f/fCd23^Cre/+ mice; data represent mean ± SEM; **P = 0.0058, Mann-Whitney U test, two-tailed p-value). b, Innate immune cell subsets; c, CD4⁺ T cells; d, CD8⁺ T cells were assessed at d7. b-d, n = 8 mice per group, combined from two independent experiments (Mann-Whitney U test, two-tailed p-value). e, CD4⁺ T cells and f, CD8⁺ T cells were assessed at d21. n = 6 mice per group, combined from two independent experiments (Mann-Whitney U test, two-tailed p-value). g, Sort-purified CD44^hiCD8⁺ cells from Cd23^Cre/+ and Bmi1^f/fCd23^Cre/+ mice at d14 post-infection were seeded in wells with splenocytes so that effector (gp33⁺CD8⁺) to target ratio was either 2.5:1 or 1:1; n = 4 mice per group (Mann-Whitney U test, two-tailed p-value). h, Mean fluorescence intensity of IFNγ in gp33⁺CD8⁺ T cells; n = 5 mice per group (Mann-Whitney U test, two-tailed p-value). i, Histological analysis of uninfected spleens from Cd23^Cre/+ and Bmi1^f/fCd23^Cre/+ mice from an individual experiment; B220 (cyan), CD3 (magenta). Scale bar = 100μm.

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