Extended Data Fig. 7: PC are decreased in response to a small molecule inhibitor to BMI-1. | Nature Immunology

Extended Data Fig. 7: PC are decreased in response to a small molecule inhibitor to BMI-1.

From: Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection

Extended Data Fig. 7

a, b, Representative flow cytometric plots of CTV-labelled wild-type B cells cultured with LPS and IL-4, and in the presence of PTC-209 at the indicated concentrations. Cells were assessed by flow cytometry for (a) ASC markers and (b) cell division, as determined by the dilution of CTV. c, Representative images of histological analysis of spleens 12d post-infection from Cd23Cre/+ and Bmi1f/fCd23Cre/+ mice treated with either the vehicle control or PTC-028; B220 (cyan), CD3 (magenta). Two examples of B cell follicles per individual mouse; two individual mice within each experimental group shown. Scale bar = 100μm.

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