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THE INFLAMMASOME

Viral protein activates the NLRP1 inflammasome

Nature Immunology volume 23, pages 822–824 (2022)Cite this article

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Inflammasomes function as immune-signaling platforms that assemble following pathogen detection. Direct binding of a viral protein to NLRP1 and the disruption of a previously unknown autoinhibitory NRLP1 complex drive the activation of the NLRP1 inflammasome independently of the proteasome.

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Fig. 1: Proteasome-dependent and independent activation of NLRP1.

References

  1. Chavarría-Smith, J. & Vance, R. E. Immunol. Rev. 265, 22–34 (2015).

    Article  PubMed  Google Scholar 

  2. Chui, A. J. et al. Science 364, 82–85 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Sandstrom, A. et al. Science 364, eaau1330 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Yang, X. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01199-x (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Broz, P. & Dixit, V. M. Nat. Rev. Immunol. 16, 407–420 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. Hollingsworth, L. R. et al. Nature 592, 778–783 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Huang, M. et al. Nature 592, 773–777 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Tsu, B. V. et al. Elife 10, e60609 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Robinson, K. S. et al. Science 370, eaay2002 (2020).

    Article  CAS  PubMed  Google Scholar 

  10. Robert Hollingsworth, L. et al. Nat. Commun. 12, 189 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Bauernfried, S., Scherr, M. J., Pichlmair, A., Duderstadt, K. E. & Hornung, V. Science https://doi.org/10.1126/science.abd0811 (2021).

    Article  PubMed  Google Scholar 

  12. Fenini, G. et al. J. Invest. Dermatol. 138, 2644–2652 (2018).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Immunobiology, University of Lausanne, Epalinges, Switzerland

    Ella Hartenian & Petr Broz

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  1. Ella Hartenian
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  2. Petr Broz
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Correspondence to Petr Broz.

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The authors declare no competing interests.

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Hartenian, E., Broz, P. Viral protein activates the NLRP1 inflammasome. Nat Immunol 23, 822–824 (2022). https://doi.org/10.1038/s41590-022-01226-x

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