Extended Data Fig. 5: Acute phase of IAV infection is related to bacterial super-infection.

(a) Schema of respiratory IAV infection followed by challenge with Streptococcal pneumoniae (S.p.) i.t. at 2 × 107 cfu per mouse on day 7 post viral infection. (b-d) Body weight change (b), illness score (c), and survival (d) of mice after bacterial challenge. Data are presented as mean ± SEM, and are representatives of two independent experiments with n = 6 mice per group. Two-tailed Student t test was performed for comparisons between two groups. Log-rank (Mantel-Cox) test was used for comparison of survival curves.