Extended Data Fig. 5: Co-regulated immune cell clusters by vaccine status. | Nature Immunology

Extended Data Fig. 5: Co-regulated immune cell clusters by vaccine status.

From: Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology

Extended Data Fig. 5: Co-regulated immune cell clusters by vaccine status.

a-d, Co-regulated cell modules (‘clusters’) from Vaccinated participants’ myeloid (a) and lymphoid/functional (c) cell populations, or Unvaccinated participants’ myeloid (b) and lymphoid/functional (d) cell populations determined by average frequency (% parent) of individual cell populations with significant positive Pearson’s bivariate correlation. Lymphoid/functional panel cell frequencies represent the average frequency (% parent) across virus (MOI = 4A/Michigan/45/2015 H1N1pdm09 or A/Singapore/INFIMH-16-019/2016 H3N2) and peptide (1–5 μM /peptide pools containing M1, NP, PB1) stimulation groups. P values were adjusted using false discovery rate (FDR; q) correction for multiple comparisons with significance q ≤0.05 denoted with color; not significant (blank).

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