Extended Data Fig. 8: scRNA-seq analysis revealed similar expression profiles between TIR-based CAR-iMACs and M1-like macrophages.
From: A second-generation M1-polarized CAR macrophage with antitumor efficacy
a, The heatmap comparing the gene expression profile of a set of M1 and M2-associated genes for EGFRvIII-targeting truncated CAR-iMACs, TIR-CAR-iMACs, and CD3ζ-TIR-CAR-iMACs to that of stimulated M1-like, M2-like and unstimulated iMACs. b, Hierarchical cluster tree showing the relationship of the truncated CAR-iMACs, TIR-CAR-iMACs, and CD3ζ-TIR-CAR-iMACs with stimulated M1-like, M2-like, and unstimulated iMACs. c, The heatmap comparing the gene expression profile of a set of M1 and M2-associated genes in CD80+ and nonCD80 cells in truncated CAR-iMACs, TIR-CAR-iMACs, and CD3ζ-TIR-CAR-iMACs to that of stimulated M1-like, M2-like and unstimulated iMACs. d, Hierarchical cluster tree showing the relationship of CD80+ and nonCD80 cells in truncated CAR-iMACs, TIR-CAR-iMACs, and CD3ζ-TIR-CAR-iMACs with stimulated M1-like, M2-like, and unstimulated iMACs. The data of IPSDM MAC, IPSDM M1, and IPSDM M2 were obtained from the GEO database (GSE55536).
