Extended Data Fig. 5: The frequency of various macrophage or DC clusters did not differ based on sex.
(a) Heatmap of differentially expressed genes (rows) of different clusters (columns). Heatmap colors indicate Z-transformed expression of genes in each row, with scale depicted in legend. Annotations (left) highlight representative genes with high differential gene expression within each cluster, relative to other clusters. Colors of gene names indicate corresponding clusters in Fig. 3a. (b) The percentage (x-axis) of each macrophage/DC cluster (y-axis) out of total MNPs in each patient (n = 7 human adult samples, n = 9 human pediatric samples). Black and white squares represent male and female patient, respectively. Bars depict means with error bars representing standard deviation. Multiple two-sided student′s t-test was applied and n.s. represents not significant.
