Extended Data Fig. 6: Subset-specific Tcf1 binding patterns in tumor-reactive CD8 T cells. | Nature Immunology

Extended Data Fig. 6: Subset-specific Tcf1 binding patterns in tumor-reactive CD8 T cells.

From: Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement

Extended Data Fig. 6: Subset-specific Tcf1 binding patterns in tumor-reactive CD8 T cells.The alternative text for this image may have been generated using AI.

a, Summary table of Tcf1 differentially binding regions (DBRs) numbers among naïve P14 (Tn), Tpex from tdLN (LN-Tpex) and Tpex from tumors (TU-Tpex). Two-sided empirical Bayes moderated t-test, FC > 2, P < 0.05. b,f, Signal enrichment heatmap of Tcf1 DBRs between LN-Tpex versus Tn (FC > 2, FDR < 0.05) (b) and TU-Tpex versus LN-Tpex (FC > 2, P < 0.05) (f). c,g, Spearman’s correlation of differential chromatin accessibility with differential Tcf1 binding between indicated groups. Gene region counts in each quadrant (n) and correlation coefficient (r) indicated in each graph. d,h, Top TF motifs enriched among the DBRs of indicated subsets. e,i, Heatmap of Tcf1 binding intensity at representative gene loci.

Back to article page