Extended Data Fig. 2: Tpex-associated programs are minimal in suboptimally primed T cells in tdLNs.
From: Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement
a–f Related to scRNA-seq in Fig. 1f, naïve T cell cluster 1 and cluster 9 (low cell count) excluded from analysis. a, Cell number in each cell cluster. b, UMAP colored by cell cycle phases (left) and percentage of cells in each phase (right). c, Barplot displaying percentage of cells in each cell cluster. d, Pathway enrichment analysis of differentially expressed genes (DEGs) in each cluster. Bubble graph displays the top enriched pathways determined by log(q-value). e, Heatmap of the top 10 DEGs for each cluster. f, Relative mRNA expression of representative genes.
