Extended Data Fig. 3: Cell composition dynamics of 25 peripheral immune cell subsets across 13 age groups.
a. Stacked bar graph showing the average proportion of each cell subset within total PBMCs based on scRNA-seq analyses across 13 age groups. b–d. Scatter plots showing the correlation between age and the proportion of each cell subset based on the scRNA-seq analyses in Fig. 1d. (b) Cell subsets significantly positively correlated with age, (c) cell subsets significantly negatively correlated with age, (d) cell subsets enriched in certain age groups. e–g. Scatter plots showing the correlation between age and the proportion of each cell subset based on the CyTOF analyses. (e) Cell subsets significantly positively correlated with age, (f) cell subsets significantly negatively correlated with age, (g) cell subsets enriched in certain age groups. In box plots b–g, median (center line), first and third quartiles (box), and extra 1.5× interguartile ranges (whiskers) are shown. In b, c, e, and f, Spearman correlation coefficient ρ and P values are indicated. A P value < 0.05 was considered statistically significant.
