Extended Data Fig. 7: Functional difference between B_BCR⁺GNLY⁺ cells and other peripheral immune cells with cytotoxic functions.

a. Upset plots showing the number of shared upregulated DEGs in B_BCR⁺GNLY⁺ cells compared with that in seven cytotoxic T cell subsets including CD4_TEM_GNLY, CD8_TCM_HAVCR2, CD8_TEM_ZNF683, CD8_TEM_CMC1, CD8_TEM_GNLY, CD8_MAIT_SLC4A10, and γδ T cells. b. Upset plots showing the number of shared upregulated DEGs in B_BC ⁺GNLY⁺ cells compared with that in three cytotoxic NK cell subsets including NK_CD56^low, NK_CD56^high, and NK_Proliferating cells. c. Dot plots showing the representative enriched biological processes of upregulated DEGs in B_BCR⁺GNLY⁺ cells compared with those in seven cytotoxic T cell subsets. d. Dot plots showing the representative enriched biological processes of upregulated DEGs in B_BCR⁺ GNLY⁺ cells compared with those in three cytotoxic NK cell subsets. e. Box plots showing the expression score of cytotoxicity in B_BCR⁺GNLY⁺ cells and seven cytotoxic T cell and three cytotoxic NK cell subsets. Box plots show median (center line), first and third quartiles (box), and extra 1.5× interquartile ranges (whiskers) and the black line indicates LOESS regression. The dashed line indicates the median score of cytotoxicity in B_BCR⁺GNLY⁺ cells. P values were determined by the two-sided unpaired Wilcoxon rank-sum test. A P value < 0.05 was considered statistically significant. In c and d, P values were determined by hypergeometric test.

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