Extended Data Fig. 10: A graphic summary of the novel insights from this study. | Nature Immunology

Extended Data Fig. 10: A graphic summary of the novel insights from this study.

From: Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age

Extended Data Fig. 10

We developed a comprehensive single-cell atlas of human peripheral immune cells across the lifespan from newborns to the elderly. Single-cell multi-omics analyses were performed to capture the diversity and dynamic trajectories of peripheral immune cells, revealing key age-specific features: a newly identified cytotoxic B-cell population enriched in children, expansion of mucosal-associated invariant T (MAIT) cells during adolescence, distinct aging patterns in naive CD4+ and CD8+ T cells, and clonal expansions of CD8+ T cells in both young and elderly individuals. Additionally, we constructed an immune age prediction model, which estimates immune age and identifies potential immune dysfunction. Created in BioRender. Huang, T. (2024) https://BioRender.com/a58r007.

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