Extended Data Fig. 5: WTspecific and Shared program scoring to T cells activated +/- TGFβ and IL-2.
From: PD-1 is requisite for skin TRM cell formation and specification by TGFβ
a. Gene Set Variation Analysis score of Shared (purple) and WTspecific (red) transcripts upregulated in skin OT-I vs naïve controls (Sharedup, WTspecific Up, Y-axis) across the transcriptomes from TGFβ/IL2/TGFβ + IL2 stimulated OT-I (GSE125471). Gray boxes represent relative activity of an equal number of random probes. The scaled GSVA score was modelled using MEM (see Methods) with treatment as a fixed effect and a random intercept for each experiment.
