Fig. 6: ILCs rapidly respond to HIV stimulation with transcriptional changes. | Nature Immunology

Fig. 6: ILCs rapidly respond to HIV stimulation with transcriptional changes.

From: Spatial and functional diversity of innate lymphoid cells in the human female genital tract may contribute to antiviral responses to HIV

Fig. 6: ILCs rapidly respond to HIV stimulation with transcriptional changes.The alternative text for this image may have been generated using AI.

a, Representative uniform manifold approximation and projection (UMAP) visualization of lineage-negative genital cells. b, UMAP plot of IL7R expression in lineage-negative genital cells from the EM, END and ECT. c,d, Gene expression of common human ILC (c) and NK-cell-associated genes (d). e–h, Gene expression for ILC1 (e), intraepithelial ILC1 (f), ILC3 (g) and LTI-like cells (h). i, Volcano plot of differentially expressed genes between control and HIV. Paired comparisons were done with the Wilcoxon non-parametric test (two-sided). Red indicates P ≤ 0.05. j,k, Transcripts significantly upregulated (j) and downregulated (k) in response to HIV in genital ILCs. Red denotes HIV-stimulated; blue represents control. All have adjusted P ≤ 0.05. l, Gene Ontology terms from upregulated genes (P ≤ 0.05) with HIV stimulation. Fisher’s exact test with false discovery rate (FDR) correction. FDR is shown by color; bubble size is the number of genes. n = 3 tissues (EM, END, ECT).

Back to article page