Extended Data Fig. 5: Weight curves of IAV-infected pDC SBMC mice deficient in pDCs or in molecules involved in Tlr7/Myd88/Irf7 signaling pathway. | Nature Immunology

Extended Data Fig. 5: Weight curves of IAV-infected pDC SBMC mice deficient in pDCs or in molecules involved in Tlr7/Myd88/Irf7 signaling pathway.

From: Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

Extended Data Fig. 5: Weight curves of IAV-infected pDC SBMC mice deficient in pDCs or in molecules involved in Tlr7/Myd88/Irf7 signaling pathway.

a–c, The weight of indicated IAV-infected mice was regularly measured up to 3-4 weeks after infection. Data are represented as percentages of the weight at day 0 of the infection. Mice reaching the end points were euthanized. d, Clinical scores of indicated IAV-infected SBMC were evaluated daily based on weight loss, eye closure, appearance of the fur, posture, and respiration. a, b, Pool of two independent experiments (8 CTR, 7 Myd88KO and 10 pDC-less SBMC in a; 8 CTR and 9 Tlr7KO SBMC in b); c, d, Pool of three independent experiments (n = 12 for each strain). e, Histological score was performed on the lungs of indicated SBMC at day 8 after infection. n = 9 for each pDC SBMC type. Data are represented as mean +/− s.e.m.

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