Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Report
  • Published:

Progress on the pathway to long COVID treatments

Nature Immunology volume 26, pages 2126–2129 (2025)Cite this article

Subjects

The US National Institute of Allergy and Infectious Diseases and Foundation for the National Institutes of Health convened a 2-day workshop announcing four agents to enter RECOVER–Treating Long COVID clinical trials and obtained input on future directions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Pathogenesis of long COVID.

References

  1. Hou, Y. et al. Open Forum Infect. Dis. 12, ofaf533 (2025).

    Article  PubMed  PubMed Central  Google Scholar 

  2. CDC. Long COVID basics https://www.cdc.gov/long-covid/about/index.html (2025).

  3. Funk, A. L. et al. JAMA Netw. Open 5, e2223253 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Lopez-Leon, S. et al. Sci. Rep. 12, 9950 (2022).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Pellegrino, R., Chiappini, E., Licari, A., Galli, L. & Marseglia, G. L. Eur. J. Pediatr. 181, 3995–4009 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Gross, R. S. et al. JAMA 332, 1174–1188 (2024).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Bombardieri, A. M. & Denoue, C. F. Reg. Anesth. Pain. Med. https://doi.org/10.1136/rapm-2025-106879 (2025).

    Article  PubMed  Google Scholar 

  8. Duricka, D. & Liu, L. Auton. Neurosci. 254, 103195 (2024).

    Article  PubMed  Google Scholar 

  9. Metz, T. D. et al. Obstet. Gynecol. 144, 411–420 (2024).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Jaswa, E. G. et al. JAMA Netw. Open 7, e2439792 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Vrantsidis, D. M. et al. JAMA Netw. Open 7, e2443697 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Swank, Z. et al. Clin. Microbiol. Infect. 30, 1599–1605 (2024).

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

The coauthors acknowledge the RECOVER-TLC workshop organizing committee: S. J. Adam (FNIH); L. R. Baden (Brigham and Women’s Hospital, Harvard University); J. Burns (Boston Children’s Hospital, Harvard University); H. Davis (Patient-Led Research Collaborative); S. E. Dunsmore (US National Center for Advancing Translational Sciences); L. J. Fine (US National Heart, Lung, and Blood Institute (NHLBI)); R. S. Gross (New York University); L. Gutmann (Indiana University); S. L. Hodder (West Virigina University); L. Jones (MEAction); J. A. Krishnan (University of Illinois Chicago); E. F. Lewis (Stanford University); C.-K. Liang (NIAID); J. P. Menetski (FNIH); S. Mohandas (Children’s Hospital Los Angeles); M. Pennini (FNIH); J. H. Powers III (NIAID); S. W. Read (NIAID); Y. D. Rosenberg (NHLBI); E. Roy (FNIH); U. Singh (University of Iowa); S. S. Spudich (Yale University); M. S. Stockwell (Columbia University); L. Tannenbaum (Open Medicine Foundation); K. M. Tomashek (NIAID); C. B. Wright (US National Institute of Neurological Disorders and Stroke); and A. B. Yonts (Children’s National Hospital).

Author information

Authors and Affiliations

  1. National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA

    Robert W. Eisinger, Joseph J. Breen, John Beigel & Jeffery K. Taubenberger

  2. Foundation for the National Institutes of Health, North Bethesda, MD, USA

    Elizabeth Geerling & Julie Gerberding

Authors
  1. Robert W. Eisinger
    View author publications

    Search author on:PubMed Google Scholar

  2. Joseph J. Breen
    View author publications

    Search author on:PubMed Google Scholar

  3. John Beigel
    View author publications

    Search author on:PubMed Google Scholar

  4. Elizabeth Geerling
    View author publications

    Search author on:PubMed Google Scholar

  5. Julie Gerberding
    View author publications

    Search author on:PubMed Google Scholar

  6. Jeffery K. Taubenberger
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Robert W. Eisinger.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Eisinger, R.W., Breen, J.J., Beigel, J. et al. Progress on the pathway to long COVID treatments. Nat Immunol 26, 2126–2129 (2025). https://doi.org/10.1038/s41590-025-02336-y

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41590-025-02336-y

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research