Extended Data Fig. 6: Acrolein scavenger attenuates Akt/mTOR/S6 pathway of CD8+ T cells in TME. | Nature Immunology

Extended Data Fig. 6: Acrolein scavenger attenuates Akt/mTOR/S6 pathway of CD8+ T cells in TME.

From: Active aldehydes accelerate CD8+ T cell exhaustion by metabolic alteration in the tumor microenvironment

Extended Data Fig. 6

MFI of pAkt, pmTOR, pS6 and Glut1 in PD-1+ CD8+ T cells in MC38 tumors on day 10 from WT female mice treated with anti-PD-L1 mAb and N-benzylhydroxylamine (NBHA) as indicated in Fig. 7b (Ctrl, n = 8 mice; the other groups, n = 6 mice). Data are means ± SEMs. P values were determined using unpaired two-tailed Student’s t tests. *P < 0.05. Data are representative of two independent experiments with similar results.

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