Fig. 6: Lipid radical and acrolein scavengers recover antitumor immunity attenuated by FAO dysfunction. | Nature Immunology

Fig. 6: Lipid radical and acrolein scavengers recover antitumor immunity attenuated by FAO dysfunction.

From: Active aldehydes accelerate CD8+ T cell exhaustion by metabolic alteration in the tumor microenvironment

Fig. 6

a, MC38 tumor growth in littermate Ctrl (Hadhaflox/flox) and KO (Hadhaflox/flox Cd4-Cre) male mice intraperitoneally (i.p.) treated with α-tocopherol (VtE) (2 mg kg−1) or dimethylsulfoxide (DMSO) (Ctrl) every 3 days from day 7 (n = 5 mice). Statistical analysis on day 28. b, MC38 tumor growth in littermate Ctrl and KO female mice i.p. treated with NBHA (100 mg kg−1) or PBS (Ctrl) every 3 days from day 7 (n = 5 mice). Tumor growth in female mice is usually slower than that in male mice. Statistical analysis on day 16. c,d, MFI of pAkt and pS6 (c) and frequencies of D1–D4 cells (d) on day 10 among PD-1+CD8+ T cells in the TME from KO male mice treated with NBHA or PBS (Ctrl) (n = 5 mice). Data are mean ± s.e.m. P values were determined using unpaired two-tailed Student’s t-tests (a,b). *P < 0.05; **P < 0.01. All data are representative of two or more independent experiments with similar results.

Back to article page