Extended Data Fig. 2: EMPEM analysis of the serum from WIN332-primed NHPs. | Nature Immunology

Extended Data Fig. 2: EMPEM analysis of the serum from WIN332-primed NHPs.

From: Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates

Extended Data Fig. 2

a, b. Negative staining electron microscopy (nsEM) densities of WIN332 Env (gray) bound to Fabs from NHP2 (blue and green) (a) and NHP3 (red) (b). WIN332 density is modelled on PDB6ORO. c,d. Comparison of the NHP2 (c) and NHP3 (d) top binder Fab densities with published Fabs EPTC112 (pink), BG18 (orange), and PGT121 (cyan). e. TZM-bl neutralization assay to determine the activity of the NHP serum in Fig. 2h against the control Murine Leukemia Virus (MLV).

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