Extended Data Fig. 7: Spatial transcriptomic visualization of Ccl2 expression in IMs and recMacs in lung TME of adenocarcinoma and melanoma.
From: Chemokine-defined macrophage niches establish spatial organization of tumor immunity
(a) Spatial expression analysis of Vcan, Mmp12 and Ccl2 in lungs of WT C57BL/6 mice 16 days after intravenous injection of 4×105 KPAR1.3 adenocarcinoma (n = 2) and B16F10 melanoma cells (n = 2). Scale bar, 1000 µm. (b) High-resolution imaging of spatial transcriptomics (as in a) showing that cellular expression of Vcan (green), Mmp12 (blue), and Ccl2 (orange). Scale bar, 100 µm Note: Endothelial cells, CD206hi IMs and DCs can also express Ccl2, data not shown.
