Fig. 6: Overlap of gene expression signatures between HIV elite controllers and CA-vDNAlo RMs.
From: TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size
a, Upregulated pathways in T cell subsets from CA-vDNAlo RMs and ECs. Larger nodes represent pathways, and the size of the nodes reflects the number of DEGs in each pathway. Smaller nodes represent shared LEGs and labeled nodes indicate genes from ECs that overlap with the DEGs from the CA-vDNAlo RMs. IRF9, a target of C/EBP-β is indicated in red. Colors inside the nodes indicate the cell subset in which the genes or pathways are statistically significant. b, Downregulated pathways in T cell subsets from CA-vDNAlo RMs and ECs. Targets of C/EBP-β are labeled in blue. c, Upregulated pathways in myeloid subsets and FDCs from CA-vDNAlo RMs and ECs. d, Downregulated pathways in myeloid subsets and FDCs from CA-vDNAlo RMs and ECs. Significant DEGs and pathways were obtained from analysis described in the legends of Fig. 4. Additional information about ECs’ gene signatures is provided in the legends of Fig. 4d and Methods section. n = 7 combo-treated RMs for all the figures in the panel.
