Extended Data Fig. 3: Interplay between IFN and TGF-β in the modulation of antivirals.
From: TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size
A. Cytograms (top panels) and bar graphs (bottom panels) representing the expression of IFIT1, APOBEC3G and MX2 at baseline (that is, with or without IFN-β stimulation, before labeling, HIV infection and co-culture) in cells from healthy human donors. Shown are FMO (gray), UNS (dotted lines) and IFN-β-stimulated (blue). Statistical significance was assessed using a two-tailed paired t-test. Error bars represent mean ± SEM. n = 6 healthy donors. Statistical significance was assessed using the Friedman test followed by uncorrected Dunn’s multiple-comparisons test; *P < 0.05, **P < 0.01, ***P < 0.001. FMO: fluorescence minus one; HDAC: histone deacetylase; IFN: interferon; PBMCs: peripheral blood mononuclear cells; TCM, TTM and TEM: central, transitional and effector memory T cells, respectively; UNS: unstimulated.
