Extended Data Fig. 2: Tumor infiltration hits identified in vivo across different breast cancer models. | Nature Immunology

Extended Data Fig. 2: Tumor infiltration hits identified in vivo across different breast cancer models.

From: Engineering NK and T cells with metabolite-sensing receptors to target solid tumors

Extended Data Fig. 2: Tumor infiltration hits identified in vivo across different breast cancer models.

(a-g) Fold change of sgRNAs in tumor vs. lung samples or NK cell library shown for sgRNAs targeting indicated genes. Combined analysis of all in vivo breast cancer models when comparing tumors to NK-92 cell library samples (a). In vivo screen in hIL-2-NOG mice (b,c) and NSG mice with subcutaneous MDA-MB-231 tumors (d,e), and in vivo screen in NSG mouse with orthotopic MDA-MB-231 tumors (f,g).

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