Extended Data Fig. 5: Lentiviral vectors expressing shFNDC5 did not cause motor impairment or affect body weight gain in mice. | Nature Medicine

Extended Data Fig. 5: Lentiviral vectors expressing shFNDC5 did not cause motor impairment or affect body weight gain in mice.

From: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

Extended Data Fig. 5

a,b, Distance traveled (a) and mean velocity (b) of mice allowed to explore an open field arena for 5 min (N = 9 mice for shCtrl, 10 mice each for shFNDC5 (1) and (2) groups). Data are shown as mean ± s.e.m. c, Body weight measured 0, 14 or 28 days after lentiviral injections (N = 10 mice per group; one-way ANOVA followed by Holm-Sidak post-test). Data are shown as mean ± s.e.m. No significantly statistical difference was found among groups.

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