Extended Data Fig. 3: Chordoma cells are less sensitive to CDK4/6 and CDK8/19 inhibitors. | Nature Medicine

Extended Data Fig. 3: Chordoma cells are less sensitive to CDK4/6 and CDK8/19 inhibitors.

From: Small-molecule targeting of brachyury transcription factor addiction in chordoma

Extended Data Fig. 3: Chordoma cells are less sensitive to CDK4/6 and CDK8/19 inhibitors.

a, Response of chordoma cells to compounds targeting CDK4/6 and CDK8/19 proteins. Four chordoma cell lines were treated with indicated concentrations of compounds and assayed for cell viability after 6 d with CellTiter-Glo. Response data are represented by a fitted curve to the mean fractional viability at each concentration relative to vehicle-treated cells; error bars represent the s.e.m. (n = 4 biological samples measured in parallel). b, Immunoblot analysis of UM-Chor1 cells treated with indicated concentrations of inhibitors or DMSO for 24 h. The experiment was performed twice for CCT251545 (one representative experiment displayed) and once for other compounds.

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