Extended Data Fig. 4: Transfer of a healthy, exclusively breast-fed infant microbiota protects against an anaphylactic response to sensitization with BLG plus cholera toxin.
From: Healthy infants harbor intestinal bacteria that protect against food allergy
a, Change in core body temperature at indicated time points following first challenge with BLG of mice colonized with feces from breast-fed healthy or CMA infant donors (n = 13 mice per group, collected from at least 2 independent experiments). b–d, Serum BLG-specific IgE (b), BLG-specific IgG1 (c) and mMCPT-1 (d) from mice in a. Four of the BLG plus cholera toxin-sensitized CMA-colonized mice died of anaphylaxis following challenge. For a, symbols represent mean, and bars represent s.e.m. For b–d, symbols represent individual mice, and bars represent mean + s.e.m. Linear mixed-effect models were used to compare groups in a and two-sided Student’s t-test in b after log transformation. The two human breast-fed fecal donors are described in Supplementary Table 2. *P < 0.05.
