Extended Data Fig. 6: A mutation in lncOb causes dysregulation of quantitative leptin expression (regular diet).
From: Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
a, Seven-week-old male (WT, n = 9; lncOb–/–, n = 7) and female (WT, n = 6; lncOb–/–, n = 9) mice were fed a regular diet for 20 weeks and body weight was monitored (shaded regions represent means ± s.e.m). b, Fat mass was measured by EchoMRI in male (WT, n = 9; lncOb–/–, n = 7) and female (WT, n = 6; lncOb–/–, n = 9) mice after 20 weeks of a regular diet. Values are means ± s.e.m. P values were calculated by two-tailed Student’s t-test. c, Leptin levels (ng/ml) were measured by ELISA and are plotted against fat mass (grams) for regular diet (RD)-fed mice (WT, n = 13; lncOb–/–, n = 14) (squares, males; circles, females). For a data were analyzed by a linear mixed model with an AR(1) correlation structure, and for c data were analyzed by linear regression.
