Extended Data Fig. 4: Morphological changes in the NPCs upon DCHS1 and FAT4 deletion. | Nature Medicine

Extended Data Fig. 4: Morphological changes in the NPCs upon DCHS1 and FAT4 deletion.

From: Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia

Extended Data Fig. 4

a–c, Micrographs of sections of KO cerebral organoids day 40 immunostained for NESTIN. Arrows indicate the disrupted morphology of NPCs (b,c). d–f, Micrographs of sections of control organoids electroporated with miRNA against DCHS1 or FAT4 at day 42 and analyzed at day 49. Arrows indicate the disrupted morphology upon downregulation of DCHS1 and FAT4 (e,f). a–c, b = 2, o = 6 per condition; d–f, b = 2, o = 6 per condition. Dotted lines highlight ventricles (V). Scale bars, 30 µm.

Back to article page