Extended Data Fig. 7: Multidimensional cardiac risk assessment.
a, Distribution of ASCVD risk scores (n = 35 participants, 36 measurements) and cardiovascular imaging and physiology measures that have been established as cardiovascular risk markers. (Abbreviations: RWT-relative wall thickness, LV GLS-left ventricular global longitudinal strain, E/e’ - ratio of mitral peak velocity of early filling (E) to early diastolic mitral annular velocity (e’), PWV-pulse wave velocity). Please note that thresholds for PWV are age-related. Box plots were derived to display quartiles (Q1, median, Q3) with the upper whisker being Q3 + 1.5 × (interquartile range) and the lower whisker extending to Q1 − 1.5 × (interquartile range) or the lowest data point. b, Ultrasound of carotid plaque (6 participants out of 35 had an ultrasound finding of carotid plaque) and relative distribution of ASCVD risk score, HbA1C and LV GLS in function of presence or absence of carotid plaque (Student’s t-test (two-sided) was used to evaluate differences between groups; n = 35, 36 measurements) (Abbreviations: CCA-common carotid artery; IJV-internal jugular vein). Error bars represent one standard deviation from the mean (upper edge of box). c, Correlation network of selected metrics collected during cardiovascular assessment (Spearman correlation (two-sided) with q < 0.2; n = 35 participants with 36 measurements). d, Composite Z score of ZOBX723 (unstable angina with stent placement) and ZNED4XZ (mild stroke with full recovery and transition to diabetes). For ZOBX723, day 829 occurred 3 weeks post-stent placement. Day 679 was a mid-infection time point. For ZNED4XZ, day 699 was the time point before the participant’s transition to diabetes and day 846 was the first diabetic time point. The stroke occurred on day 307 for this individual. Gray dots represent Z scores of other participants (n = 101 with 859 samples). e, Violin plot showing the same data as d (n = 101 with 859 samples). The box plot shows the first (lower edge of box), median (middle line) and third (upper edge of box) quartiles. The upper whisker is the third quartile + 1.5 × (interquartile range) and the lower whisker is the lowest data point.
